Journal
ACTA PHARMACOLOGICA SINICA
Volume 43, Issue 10, Pages 2462-2473Publisher
NATURE PUBL GROUP
DOI: 10.1038/s41401-022-00887-6
Keywords
pyroptosis; inflammasome; caspase; GSDMD; GSDME; apoptosis
Funding
- Arkansas INBRE program [P20 GM103429]
- National Heart, Lung and Blood Institute [HL153876]
- National Eye Institute [EY030621]
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This review discusses the roles of the gasdermin protein family in anti-cancer functions and various antitumor drugs that could activate the pyroptosis pathways.
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death. In this review, we discuss the roles of the GSDM family for anti-cancer functions and various antitumor drugs that could activate the pyroptosis pathways.
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