Journal
ACTA DERMATO-VENEREOLOGICA
Volume 102, Issue -, Pages -Publisher
ACTA DERMATO-VENEREOLOGICA
DOI: 10.2340/actadv.v102.262
Keywords
melanoma; vitamin D; body mass index
Categories
Funding
- Kom op tegen Kanker (Stand up to Cancer)
- Flemish cancer society
- Anticanderfunds
- agency for Innovation by science and technology (IWT)-applied biomedical research program (TBM)
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This study aimed to confirm the well-known determinants and assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. The results showed that body mass index, seasonal time of blood sampling, vitamin D supplementation, and a specific subtype of skin and hair color had a significant effect on vitamin D status.
Vitamin D status is influenced by well-known determinants, but factors associated with low 25-hydroxyvitamin D levels in the cutaneous melanoma population are not well defined. The aim of this study was to confirm the well-known determinants and to assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. In a prospectively included cohort of 387 patients with cutaneous melanoma the association of 25-hydroxyvitamin D levels with sex, age, body mass index, time of blood withdrawal, Fitzpatrick phototype, vitamin D supplementation, score for intensity of lifetime sun exposure, smok-ing, education level, hair and skin colour, eye colour, total number of benign naevi, freckles and parameters of chronic sun damage was investigated. In addition, 25-hydroxyvitamin D levels were correlated with patho-logical parameters of the primary tumour and melanoma stage (8th edition of the American Joint Committee on Cancer (AJCC). Univariate and multivariate logistic regressions were performed using R software. The following factors had a significant effect on vitamin D status: body mass index, seasonal time of blood sampling, vitamin D supplementation, and a subtype of skin, and hair colour.
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