Journal
ACTA BIOMATERIALIA
Volume 147, Issue -, Pages 147-157Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.actbio.2022.05.047
Keywords
Hyaluronic acid; Antioxidation; Hydrogel; Glucose-responsive; Diabetic wound
Funding
- National Natural Science Foundation of China [51973243]
- Fundamental Research Funds for the Central Universities [191gzd35]
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06S029]
- Shenzhen Basic Research Project [JCYJ20190807155801657]
- Key International (Regional) Cooperative Research Projects of the National Natural Science Foundation of China [5181001045]
- Hebei DHRSS Research Fund [E201910 0 0 05]
- High-level Talents Research Start- up Project of Hebei University [5210 0 0981336]
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In this study, a glucose-responsive HA-based hydrogel platform was developed for rapid repair of diabetic wounds. The HMPC hydrogel effectively promoted angiogenesis and reduced inflammatory response, leading to the rapid recovery of diabetic wounds.
Hyaluronic acid (HA)-based antioxidant hydrogels have achieved remarkable results in diabetic wound repair. However, the realization of their glucose-responsive antioxidant functions remains a significant challenge. In this study, we modified hyaluronic acid methacrylate (HAMA) with phenylboronic acid (PBA) and developed a glucose-responsive HA derivative (HAMA-PBA). A glucose-responsive HAMA-PBA/catechin (HMPC) hydrogel platform was then fabricated by forming a borate ester bond between HAMA-PBA and catechin. The results showed that the HMPC hybrid hydrogel not only had a three-dimensional network structure and Young's modulus similar to those of skin tissue, but also possessed biocompatibility. The HMPC hydrogel also showed unique glucose-responsive catechin release behavior and remarkable antioxidant capability, which could effectively eliminate intracellular reactive oxygen species and protect cells from oxidative stress damage (increased superoxide dismutase activity, stabilized reduced glutathione/oxidized glutathione ratio, and reduced malondialdehyde content). Additionally, in vitro and in vivo experimental results showed that the HMPC hydrogel effectively promoted angiogenesis (enhanced VEGF and CD31 expression) and reduced inflammatory responses (decreased IL-6 level and increased IL-10 level), thus rapidly repairing diabetic wounds (within three weeks). This was a significant improvement as compared to that observed for the untreated control group and the HMP hydrogel group. These results indicated the potential for the application of the HMPC hydrogel for treating diabetic wounds. Statement of significance At present, the delayed closure rate of diabetic chronic wounds caused by excessive reactive oxygen species (ROS) remains a worldwide challenge. Hyaluronic acid (HA)-based antioxidant hydrogels have made remarkable achievements in diabetic wound repair; however, the realization of their glucose-responsive antioxidant functions is a tough challenge. In this work, we developed a novel HA-based hydrogel platform with glucose-responsive antioxidant activity for rapid repair of diabetic wounds. In vitro and in vivo experimental results showed that the HMPC hydrogel could effectively promote angiogenesis (enhanced VEGF and CD31 expression) and reduce inflammatory response (decreased IL-6 level and increased IL-10 level), thus rapidly repairing diabetic wounds (within 3 weeks). These results indicated the potential of the HMPC hydrogel for application in diabetic wound treatment. (c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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