Journal
ACS NANO
Volume 16, Issue 6, Pages 9130-9141Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c01206
Keywords
photodynamic therapy; antimicrobial; aggregation-induced emission; type I photosensitizers; cationization
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Funding
- Guangzhou Municipal Science and Technology Bureau [202102021224]
- Natural Science Foundation of Guangdong Province [2021A1515011901]
- Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates [2019B030301003]
- National Natural Science Foundation of China [21788102]
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This article introduces a molecular cationization approach to enhance the generation of reactive oxygen species (ROS) by aggregation-induced emission (AIE) photosensitizers, especially type I ROS, for photodynamic treatment of drug-resistant bacteria.
Photodynamic therapy as an emerging phototheranostic approach holds great potential for antibacterial treatment, but is limited by compromised reactive oxygen species (ROS) generation in an aggregate and hypoxic microenvironment. Herein, we report a molecular cationization approach to boost the ROS, especially type I ROS generation of aggregation-induced emission (AIE) photosensitizers for photodynamic treatment of drug-resistant bacteria. Such cationization reinforces the electron-accepting ability of the cationic moiety, promotes intersystem crossing (ISC), and increases electron separation and transfer processes. The resultant CTBZPyI exhibits largely enhanced ROS generation ability with predominant hydroxyl radical generation over its neutral counterpart in aggregate. Moreover, cationization also confers CTBZPyI with the bacterial binding ability and a moderate bacterial inactivation ability in the dark. Further light irradiation leads to superb antibacterial performance, which largely promotes the healing process of a MRSA-infected wound. Such a cationization strategy is expected to be a general strategy for the design of highly effective type I photosensitizers for bacterial infection treatment.
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