Journal
ACS NANO
Volume 16, Issue 4, Pages 5358-5375Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c08090
Keywords
polysilicon microparticles; bipyridinium; HeLa cells; cancer; lipid peroxidation; cytotoxicity
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Funding
- ERDF (FEDER) funds
- Spanish government [TEC2017-85059-C3-1, TEC2017-85059-C3-2-R, PID2020-115663GB-C3-1, PID2020-115663GB-C3-2]
- Consortium for Advanced Studies Abroad (CASA)
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The use of micrometric-sized vehicles can improve the selectivity of cytotoxic compounds, leading to higher efficiency in killing cancer cells.
The use of micrometric-sized vehicles could greatly improve selectivity of cytotoxic compounds as their lack of self-diffusion could maximize their retention in tissues. We have used polysilicon microparticles (Si mu P) to conjugate bipyridinium-based compounds, able to induce cytotoxicity under regular intracellular conditions. Homogeneous functionalization in suspension was achieved, where the open-chain structure exhibits a more dense packing than cyclic analogues. The microparticles internalized induce high cytotoxicity per particle in cancerous HeLa cells, and the less densely packed functionalization using cyclophanes promotes higher cytotoxicity per bipy than with open-chain analogues. The self-renewing ability of the particles and their proximity to cell membranes may account for increased lipid peroxidation, achieving toxicity at much lower concentrations than that in solution and in less time, inducing highly efficient cytotoxicity in cancerous cells.
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