Journal
ACS NANO
Volume 16, Issue 6, Pages 8662-8676Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.2c00662
Keywords
diabetic wound; adhesive hydrogel; detachable hydrogel; polyphenol chemistry; wound dressing
Categories
Funding
- Sichuan Key Research and Development Program of China [22ZDYF2034]
- NSFC [82072071, 31800798]
- Guangdong Basic and Applied Basic Research Foundation [2021B1515120019]
- Shenzhen Funds of the Central Government [2021SZVUP123]
- Fundamental Research Funds for Central Universities [202241010, 2682020ZT79]
- Pilot National Laboratory for Marine Science and Technology (Qingdao)
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A skin-friendly adhesive hydrogel patch based on protein-polyphenol complexation strategy is presented. The hydrogel exhibits a thermoresponsive network and can be activated upon contact with warm skin, while painless detachment can be achieved by placing an ice bag on the surface. The hydrogel also has immunomodulatory performance and can prevent irritation and allergic reactions during long-period contact with the skin.
Adhesive-caused injury is a great threat for infants with premature skin or diabetic patients with fragile skin because extra-strong adhesion might incur pain, inflammation, and exacerbate trauma upon removal. Herein, we present a skin-friendly adhesive hydrogel patch based on protein-polyphenol complexation strategy, which leads to a thermoresponsive network sensitive to body temperature. The adhesion of the hydrogel is smartly activated after contacting with warm skin, whereas the painless detachment is easily realized by placing an ice bag on the surface of the hydrogel. The hydrogel exhibits an immunomodulatory performance that prevents irritation and allergic reactions during long-period contact with the skin. Thus, the hydrogel patch works as a conformable and nonirritating interface to guarantee nondestructively securing bioelectronics on infant skin for healthcare. Furthermore, the hydrogel patch provides gentle adhesion to wounded skin and provides a favorable environment to speed up the healing process for managing diabetic wounds.
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