Related references
Note: Only part of the references are listed.Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains
Suzanne M. Underhill et al.
MOLECULAR PSYCHIATRY (2021)
Validation of a High-Throughput Calcium Mobilization Assay for the Human Trace Amine-Associated Receptor 1
Ann M. Decker et al.
SLAS DISCOVERY (2021)
Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists
Md Toufiqur Rahman et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases
Michael D. Schwartz et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2018)
Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake
Chunyang Jin et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Trace Amines and Their Receptors
Raul R. Gainetdinov et al.
PHARMACOLOGICAL REVIEWS (2018)
Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397
Stefano Espinoza et al.
FRONTIERS IN PHARMACOLOGY (2018)
Potent and Selective Tetrahydroisoquinoline Kappa Opioid Receptor Antagonists of Lead Compound (3R)-7-Hydroxy-N-[(1S)-2-methyl-1-(piperidin-1-ylmethyl)propyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide (PDTic)
Pauline W. Ondachi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Behavioral Effects of a Potential Novel TAAR1 Antagonist
Vincent M. Lam et al.
FRONTIERS IN PHARMACOLOGY (2018)
Synthesis and Evaluation of Orexin-1 Receptor Antagonists with Improved Solubility and CNS Permeability
David A. Perrey et al.
ACS CHEMICAL NEUROSCIENCE (2018)
Pharmacology of human trace amine-associated receptors: Therapeutic opportunities and challenges
Mark D. Berry et al.
PHARMACOLOGY & THERAPEUTICS (2017)
Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists
Thuy Nguyen et al.
ACS CHEMICAL NEUROSCIENCE (2017)
TAARgeting Addiction-The Alamo Bears Witness to Another Revolution An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference
David K. Grandy et al.
DRUG AND ALCOHOL DEPENDENCE (2016)
In Vitro Characterization of Psychoactive Substances at Rat, Mouse, and Human Trace Amine-Associated Receptor 1
Linda D. Simmler et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2016)
Effect of 1-Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin-1 Receptor
David A. Perrey et al.
ACS CHEMICAL NEUROSCIENCE (2015)
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of the 3-and 4-methyl substituents
F. Ivy Carroll et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
The importance of the 6-and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor
David A. Perrey et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers
Anja Harmeier et al.
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2015)
Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1
Stefano Espinoza et al.
NEUROPHARMACOLOGY (2015)
Discovery and structure-activity relationships study of novel thieno[2,3-b] pyridine analogues as hepatitis C virus inhibitors
Ning-Yu Wang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Further Insights Into the Pharmacology of the Human Trace Amine-Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach
Elena Cichero et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2014)
Taar1-mediated modulation of presynaptic dopaminergic neurotransmission: Role of D2 dopamine autoreceptors
D. Leo et al.
NEUROPHARMACOLOGY (2014)
A new perspective for schizophrenia: TAAR1 agonists reveal antipsychotic- and antidepressant-like activity, improve cognition and control body weight
F. G. Revel et al.
MOLECULAR PSYCHIATRY (2013)
Truncated Orexin Peptides: Structure-Activity Relationship Studies
Nadezhda A. German et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery
Arup K. Ghose et al.
ACS CHEMICAL NEUROSCIENCE (2012)
Optimisation of imidazole compounds as selective TAAR1 agonists: Discovery of RO5073012
Guido Galley et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)
The influence of lipophilicity in drug discovery and design
John A. Arnott et al.
EXPERT OPINION ON DRUG DISCOVERY (2012)
Design and Synthesis of Cannabinoid Receptor 1 Antagonists for Peripheral Selectivity
Alan Fulp et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Automated design of ligands to polypharmacological profiles
Jeremy Besnard et al.
NATURE (2012)
Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773)
Henri Stalder et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
Drug-permeability and transporter assays in Caco-2 and MDCK cell lines
Donna A. Volpe
FUTURE MEDICINAL CHEMISTRY (2011)
Automated Selection of Compounds with Physicochemical Properties To Maximize Bioavailability and Druglikeness
Taiji Oashi et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity
Florent G. Revel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Drug-Like Property Concepts in Pharmaceutical Design
Li Di et al.
CURRENT PHARMACEUTICAL DESIGN (2009)
The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system
Amyaouch Bradaia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Toward deciphering the code to aminergic G protein-coupled receptor drug design
Edwin S. Tan et al.
CHEMISTRY & BIOLOGY (2008)
One-pot synthesis of diverse 4-Di(tri)fluoromethyl-3-cyanopyridine-2(1H)-thiones and their utilities in the cascade synthesis of annulated heterocycles
Lyudmila A. Rodinovskaya et al.
JOURNAL OF COMBINATORIAL CHEMISTRY (2008)
Trace amine-associated receptor 1 modulates dopaminergic activity
Lothar Lindemann et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Trace amine-associated receptor 1 is a modulator of the dopamine transporter
Zhihua Xie et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Transport of decursin and decursinol angelate across Caco-2 and MDR-MDCK cell monolayers:: In vitro models for intestinal and blood-brain barrier permeability
Vamsi L. M. Madgula et al.
PLANTA MEDICA (2007)
A rapid functional assay for the human trace amine-associated receptor 1 based on the mobilization of internal calcium
Hernan A. Navarro et al.
JOURNAL OF BIOMOLECULAR SCREENING (2006)
Comparison of drug efflux transport kinetics in various blood-brain barrier models
Corbin J. Bachmeier et al.
DRUG METABOLISM AND DISPOSITION (2006)
In vitro models for the blood-brain barrier
P Garberg et al.
TOXICOLOGY IN VITRO (2005)
Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors
L Lindemann et al.
GENOMICS (2005)
Evaluation of the MDR-MDCK cell line as a permeability screen for the blood-brain barrier
Q Wang et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2005)
Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor
JR Bunzow et al.
MOLECULAR PHARMACOLOGY (2001)
Trace amines: Identification of a family of mammalian G protein-coupled receptors
B Borowsky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Share Paper
