Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 23, Pages 26455-26468Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.2c05114
Keywords
nanozyme; graphdiyne; piezocatalysis; reactive oxygen species; skin patch
Funding
- National Natural Science Foundation of China [31800800, 21301103]
- Natural Science Foundation of Shandong province [ZR2019BC101, ZR202103010467]
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This study reports a novel nanozyme system, zinc oxide nanorod@graphdiyne nanosheets (ZnO@GDY NR), which exhibits unique piezocatalytic enzyme mimic activity. It effectively promotes the decomposition of hydrogen peroxide (H2O2) and generation of reactive oxygen species under ultrasound irradiation, resulting in almost 100% antibacterial efficacy against multidrug-resistant pathogens. Moreover, a piezoelectric activatable nanozyme-based skin patch is developed for rapid wound disinfection.
Nanozymes are promising new-generation antibacterial agents owing to their low cost, high stability, broadspectrum activity, and minimal antimicrobial resistance. However, the inherent low catalytic activity of nanozymes tends to limit their antibacterial efficacy. Herein, a heterostructure of zinc oxide nanorod@graphdiyne nanosheets (ZnO@GDY NR) with unparallel piezocatalytic enzyme mimic activity is reported, which concurrently possesses intrinsic peroxidase-like activity and strong piezoelectric responses and effectively promotes the decomposition of hydrogen peroxide (H2O2) and generation of reactive oxygen species under ultrasound irradiation. Moreover, this piezocatalytic nanozyme exhibits almost 100% antibacterial efficacy against multidrug-resistant pathogens involving methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa in vitro and in vivo. In addition, a piezoelectric activatable nanozyme-based skin patch is developed for rapid skin wound disinfections with satisfactory hemocompatibility and cytocompatibility. This work not only sheds light on the development of an innovative piezoelectric activatable nanozyme-based skin patch for rapid wound disinfection but also provides new insights on the engineering of piezocatalytic nanozymes for nanozyme antibacterial therapy.
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