Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 11, Pages 13001-13012Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c23342
Keywords
Hp infection; nanoliposomes; tea polyphenols; neutralize stomach acid; reduce inflammatory factors
Funding
- National Natural Science Foundation of China [21807036, 21778020]
- Sci-tech Innovation Foundation of Huazhong Agriculture University [2662020LXPY007]
- Science and Technology Major Project of Guangxi [Gui Ke AA18118046]
- National Key R&D Program of China [2016YFD0500706]
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Infection with Helicobacter pylori (Hp) is a major cause of stomach cancer. This study introduces nanoliposomes that can modify the gastric acid environment to effectively treat Hp infection. Results show that these nanoliposomes can eliminate Hp infection and reduce inflammation, suggesting a potential therapeutic strategy.
Infection with Helicobacter pylori (Hp) is one of the leading causes of stomach cancer. The ability to treat Hp infection is hampered by a lack of stomach gastric acid environment. This work introduces a nanoliposome that can rapidly adjust the gastric acid environment to ensure a drug's optimal efficacy. We introduce CaCO3@Fe-TP@EggPC nanoliposomes (CTE NLs) that are composed of Fe3+ and tea polyphenols (TPs) forming complexes on the surface of internal CaCO3 and then with lecithin producing a phospholipid bilayer on the polyphenols' outer surface. Through the action of iron-TP chelate, the phospholipid layer can fuse with the bacterial membrane to eliminate Hp. Furthermore, CaCO3 can promptly consume the excessive gastric acid, ensuring an ideal operating environment for the chelate. TPs, on the other hand, can improve the inflammation and gut microbes in the body. The experimental results show that CTE NLs can quickly consume protons in the stomach and reduce the bacterial burden by 1.2 orders of magnitude while reducing the inflammatory factors in the body. The biosafety evaluation revealed that nanoliposomes have good biocompatibility and provide a new strategy for treating Hp infection.
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