Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 14, Issue 14, Pages 15911-15926Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c24131
Keywords
tryptophan-based poly(ester urea)s; electrospun mats; NO-releasing; antibacterial and antibiofilm activities; wound dressing
Funding
- National Key Research and Development Program of China [2017YFB0309001]
- Natural Science Foundation of Shanghai [18ZR1400400, 18ZR1400500, 20ZR1402100]
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In this study, tryptophan-based poly(ester urea) materials were developed for the preparation of composite mats with good biodegradation and biocompatibility. The mats were grafted with a nitric oxide donor and exhibited a prolonged NO release profile, effectively killing bacteria and disrupting biofilms. Furthermore, the mats promoted cell growth, regulated inflammatory factors, and accelerated wound healing.
Bacterial biofilms on wounds can lead to ongoing inflammation and delayed reepithelialization, which brings a heavy burden to the medical systems. Nitric oxide based treatment has attracted attention because it is a promising strategy to eliminate biofilms and heal infected wounds. Herein, a series of tryptophan-based poly(ester urea)s with good biodegradation and biocompatibility were developed for the preparation of composite mats by electrospinning. Furthermore, the mats were grafted with a nitric oxide donor (nitrosoglutathione, GSNO) to provide one type of NO loading cargo. The mats were found to have a prolonged NO release profile for 408 h with a maximum release of 1.0 mu mol/L, which had a significant effect on killing bacteria and destructing biofilms. The designed mats were demonstrated to promote the growth of cells, regulate inflammatory factors, and significantly improve collagen deposition in the wound, eventually accelerating wound-size reduction. Thus, the studies presented herein provide insights into the production of NO-releasing wound dressings and support the application of full-thickness wound healing.
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