Journal
AAPS PHARMSCITECH
Volume 23, Issue 4, Pages -Publisher
SPRINGER
DOI: 10.1208/s12249-022-02217-9
Keywords
spanlastic; nanotechnology; edge activator; drug delivery; deformable and elastic vesicle
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Nanotechnology-based drug delivery systems have revolutionized drug delivery. Spanlastics, an elastic nanovesicle, has the ability to carry a wide range of drug molecules and is suitable for various routes of administration. This review provides an overview of the composition, structure, advantages, and mechanism of drug penetration of spanlastics.
Nanotechnology-based drug delivery system has played a very crucial role in overpowering the tasks allied with the conventional dosage form. Spanlastics, an elastic nanovesicle with an ability to carry wide range of drug molecules, make it a potential drug delivery carrier. Spanlastics have extended rising curiosity for diverse sort of route of administration. They can squeeze themselves through the skin pore due to elastic and deformable nature which makes them favorable for transdermal delivery. Spanlastics consist of non-ionic surfactant or blend of surfactants. Many researchers proved that spanlastics have been significantly augment therapeutic efficacy, enhanced drug bioavailability, and reduced drug toxicity. This review summarizes various vesicular systems, composition and structure of spanlastics, advantages of spanlastics over other drug delivery systems, and mechanism of drug penetration through skin. It also gives a brief on different types of drug encapsulated in spanlastics vesicles for the treatment of various diseases.
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