4.6 Editorial Material

The AAPS Journal Theme Issue: Rising Stars in Drug Delivery and Novel Carriers

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Zwitterionic Polymer Coatings Enhance Gold Nanoparticle Stability and Uptake in Various Biological Environments

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Summary: Zwitterionic polymers have been developed as coatings for gold nanoparticles to enhance stability and uptake in biological environments. These coated nanoparticles showed reduced aggregation, improved suspension stability, decreased protein adsorption, and increased cell uptake compared to uncoated particles after exposure to biological fluids. The differences in particle fate between serum and lung lavage fluid exposures suggest that fluid composition impacts particle behavior.

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Microfluidic-Generated Immunomodulatory Nanoparticles and Formulation-Dependent Effects on Lipopolysaccharide-Induced Macrophage Inflammation

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Modulating Oral Delivery and Gastrointestinal Kinetics of Recombinant Proteins via Engineered Fungi

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The Nano-War Against Complement Proteins

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Summary: The complement cascade poses a significant barrier to targeted drug delivery and nanomedicine by opsonizing nanocarriers and leading to deleterious effects. Material properties of nanocarriers can impact complement activation, and current and future strategies are being developed to control complement and unlock the potential of nanomedicine.

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Exosomes in Atherosclerosis, a Double-Edged Sword: Their Role in Disease Pathogenesis and Their Potential as Novel Therapeutics

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Summary: Cardiovascular disease caused by atherosclerosis is a major global health concern. Exosomes secreted by various cell types play a crucial role in the development of atherosclerosis and have both atherogenic and atheroprotective functions. Enhancing the therapeutic potential of atheroprotective exosomes through drug loading and surface modification is a promising approach, but current challenges exist in exosome engineering for therapeutic applications.

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Employing Drug Delivery Strategies to Overcome Challenges Using TLR7/8 Agonists for Cancer Immunotherapy

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Summary: Toll-like receptors (TLRs) play a crucial role in cancer immunotherapy, with TLR7 and TLR8 being identified as potential therapeutic targets. Despite challenges such as poor drug solubility and systemic toxicity, biomaterial-based drug delivery systems have shown promise in enhancing the efficacy of TLR7/8 agonists. Additionally, combining TLR7/8 agonists with other therapies, such as checkpoint inhibitors and cancer vaccines, has demonstrated impressive anti-cancer effects.

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Pharmacokinetic Analysis of Peptide-Modified Nanoparticles with Engineered Physicochemical Properties in a Mouse Model of Traumatic Brain Injury

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Summary: Peptides play a key role in controlling the pharmacokinetic profiles of nanoparticles, particularly in the context of traumatic brain injury (TBI). The physicochemical properties of peptides on nanoparticle surfaces can significantly impact their distribution and accumulation in off-target organs, with positively charged peptides leading to increased accumulation in non-target organs but decreased accumulation in the injured brain. Understanding these relationships is crucial for the development of nanoparticle-based TBI therapeutics and has broader implications for nanotherapeutic design.

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