Journal
CCS CHEMISTRY
Volume 4, Issue 2, Pages 420-436Publisher
CHINESE CHEMICAL SOC
DOI: 10.31635/ccschem.021.202101307
Keywords
aggregation-induced emission; NIR AIE-gens; two-photon AIEgens; bio-detection; bio-imaging; image-guided therapy; microfluidics
Categories
Funding
- National Key RAMP
- D Program of China [2018YFA0902600]
- Shenzhen Science and Technology Program [KQTD20190929172743294]
- National Natural Science Foundation of China [21535001, 81730051, 21761142006]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH039, 121D11KYSB20170026]
- Shenzhen Bay Laboratory [SZBL2019062801004]
- Shenzhen Key Laboratory of Smart Healthcare Engineering [ZDSYS202008111 44003009]
- Guangdong Innovative and Entrepreneurial Research Team Program [2019ZT08Y191]
- GBA Research Innovation Institute for Nanotechnology [2020GN0110]
- Tencent Foundation through the XPLORER PRIZE
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This review summarizes the recent developments in the design strategy, bio-detection, cell imaging, tumor imaging, vascular imaging, and image-guided tumor therapy of aggregation-induced emission (AIE) fluorogens. The microfluidic approach to synthesize AIE nanoparticles (NPs) and current challenges and potentials of AIE NPs are highlighted.
Aggregation-induced emission (AIE) fluorogens produce strong, stable fluorescence upon aggregation, thus enabling a new frontier in bio-detection, cell imaging, and other biomedical applications. In this review, we summarize the recent developments of AIE fluorogen design strategy, bio-detection, cell imaging, tumor imaging, vascular imaging, and image-guided tumor therapy. We highlight a section on the microfluidic approach to synthesize AIE nanoparticles (NPs) and current challenges and potentials of AIE NPs. [GRAPHICS] .
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