Journal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
Volume 93, Issue 6, Pages 427-433Publisher
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/cjpp-2015-0038
Keywords
hepatoprotection; oxidative stress; antioxidant enzymes; pro-inflammatory cytokines; anti-inflammatory cytokines
Categories
Funding
- National Science Foundation for Post-doctoral Scientists of China [2012M521412]
- Provincial Fundamental Research Fund in Henan University of Chinese Medicine [2014KYYWF-QN01]
- Funding Scheme for Young Key Teachers of Colleges and Universities in Henan Province [2014GGJS-072]
- National Natural Science Foundation of China [81473368]
- Innovation Program for Science & Technology Leading Talents of Zhengzhou City in China's Henan Province [121PLJRC534]
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Quercetin (Que) is one of main compounds in Lysimachia christinae Hance (Christina loosestrife), and has both medicinal and nutritional value. Glycosides from Tripterygium wilfordii Hook. f. (lei going teng [the thunder duke vine]; TG) have diverse and broad bioactivities but with a high incidence of liver injury. Our previous study reported on the hepatoprotective properties of an ethanol extract from L. christinae against TG-induced liver injury in mice. This research is designed to observe, for the first time, the possible protective properties of the compound Que against TG-induced liver injury, and the underlying mechanisms that are involved in oxidative stress and anti-inflammation. The results indicated that TG caused excessive elevation in serum levels of alanine/aspartate transaminase (ALT/AST), alkaline phosphatase (ALP), gamma glutamyl transferase (gamma-GT), and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha), as well as hepatic lipid peroxidation (all P < 0.01). On the other hand, following TG exposure, we observed significantly reduced levels of biomarkers, including hepatic glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPx), and the anti-inflammatory cytokine interleukin (IL)-10, as well as the enzyme activity and mRNA expression of copper-and zinc-containing superoxide dismutase (CuZn-SOD) and catalase (CAT) (all P < 0.01). Nevertheless, all of these alterations were reversed by the pre-administration of Que or the drug bifendate (positive control) for 7 consecutive days. Therefore, this study suggests that Que ameliorates TG-induced acute liver injury, probably through its ability to reduce oxidative stress and its anti-inflammatory properties.
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