Journal
TUMOUR VIRUS RESEARCH
Volume 12, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.tvr.2021.200225
Keywords
E1A; E1B; E4; Transformation; Hallmarks of cancer; Human adenovirus
Categories
Funding
- Canadian Institute of Health Research [MOP-148689]
- Ontario Graduate Scholarship
- RGE Murray Scholarships
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Despite not being known as a causative agent of human cancers, human adenoviruses have played a significant role in advancing our understanding of the molecular basis of cancer through research on cell cycle control, gene expression, apoptosis, and cell differentiation.
Papillomaviruses, polyomaviruses and adenoviruses are collectively categorized as the small DNA tumour viruses. Notably, human adenoviruses were the first human viruses demonstrated to be able to cause cancer, albeit in non-human animal models. Despite their long history, no human adenovirus is a known causative agent of human cancers, unlike a subset of their more famous cousins, including human papillomaviruses and human Merkel cell polyomavirus. Nevertheless, seminal research using human adenoviruses has been highly informative in understanding the basics of cell cycle control, gene expression, apoptosis and cell differentiation. This review highlights the contributions of human adenovirus research in advancing our knowledge of the molecular basis of cancer.
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