Journal
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
Volume 11, Issue 6, Pages 503-512Publisher
ELSEVIER
DOI: 10.1016/j.jtcme.2021.04.004
Keywords
Genistein; Exercise; Nonalcoholic steatohepatitis; Ovariectomized
Categories
Funding
- 100th Anniversary Fund of Chulalongkorn University
- 90th Anniversary of Chulalongkorn University Scholarship
- Ratchadaphiseksomphot Endowment Fund, Bangkok, Thailand
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The study found that genistein and exercise treatments improved non-alcoholic steatohepatitis by suppressing the expression of specific proteins. However, the combination therapy did not provide additional benefits.
Background and aim: Genistein (GEN) and exercise (Ex) may be regarded as an alternative treatment for non-alcoholic steatohepatitis (NASH). However, the mechanisms behind their therapeutic effects in NASH are not well-understood. Experimental procedure: This study investigated the roles of histone deacetylase (HDAC)3 and interleukin-(IL-)13 in the NASH model of ovariectomized (OVX) rats fed with high fat high fructose (HFHF) diet. Results and conclusion: Nine weeks after being fed with HFHF diet, severe NASH pathology with mild fibrosis were seen along with an increase in HDAC3, IL-13 and matrix metalloelastase (MMP-12) expressions in OVX rats. Five weeks of either GEN or Ex treatments abrogated the increase in both HDAC3 and IL-13 expressions in OVX rats fed with HFHF diet and ameliorated NASH features, liver fibrosis and MMP-12 expression. The combination of Gen and Ex, however, did not provide additional benefits on NASH features in OVX rats fed with HFHF diet. These results suggested that GEN and Ex treatments improved HFHF diet induced NASH in OVX rats through the suppression of HDAC3, IL-13 and MMP-12 expression. (c) 2021 Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
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