Unique case of atraumatic splenic rupture in a patient with chronic lymphocytic leukaemia with Richter's transformation

Though rare, atraumatic rupture of the spleen can be a complication in certain leukaemias and lymphomas. We present a unique case of atraumatic rupture of the spleen in a patient with chronic lymphocytic leukaemia. The patient presented to the emergency department with abdominal pain; he had been on ibrutinib therapy but stopped taking the medication abruptly 6 days prior. On evaluation, he was found to have a ruptured spleen with a haemoperitoneum. Pathology of the excised spleen showed infiltration of the spleen with hyperproliferated CD5+ intermediate-to-large cells, consistent with B-cell lymphoma and favouring Richter's transformation. There are only a few available reports of patients with similar presentations identified in our literature review.

Automated summary

This case report presented a patient with atraumatic rupture of the spleen in the setting of chronic lymphocytic leukaemia with Richter's transformation confirmed on pathology. The patient presented to the emergency department with abdominal pain, and pathology showed infiltration of hyperproliferated cells in the spleen.