Journal
BMJ CASE REPORTS
Volume 14, Issue 11, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/bcr-2021-246747
Keywords
neonatal intensive care; pregnancy; materno-fetal medicine; arrhythmias; immunology
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Congenital heart block (CHB) is most commonly caused by neonatal lupus, an acquired autoimmune disease transmitted from maternal antibodies to the fetus. In this case, a full-term female neonate showed severe bradycardia at birth, later diagnosed with cardiac neonatal lupus with positive maternal anti-Ro antibodies after admission to the neonatal intensive care unit. The infant was discharged without need for a pacemaker and will have regular follow-up with a paediatric cardiologist.
The most common cause of congenital heart block (CHB) is neonatal lupus, an acquired autoimmune disease caused by transplacental transfer of maternal antibodies to the fetus. A full-term female neonate was admitted to neonatal intensive care unit for severe bradycardia with stable haemodynamics. The mother, showing no clinical symptoms or any particular history, was transferred to our tertiary centre for profound fetal bradycardia. At birth, the infant's ECG showed a third-degree atrioventricular block and echocardiography was normal. Cardiac neonatal lupus was confirmed with positive maternal anti-Ro antibodies. Under close monitoring, the infant tolerated the bradycardia well (median 67 beats per minute (bpm)) and was discharged on day 6 of life. There was no indication for pacemaker, but she would be on regular follow-up with a paediatric cardiologist. This article holds an important insight as it is the first confirmed case of autoimmune CHB in Cambodia in which the mother's antibody was found only after diagnosis on the neonate.
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