Journal
MYCOLOGY-AN INTERNATIONAL JOURNAL ON FUNGAL BIOLOGY
Volume 13, Issue 1, Pages 68-75Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21501203.2021.1994479
Keywords
Candida auris; antifungal resistance; mating type locus; virulence; morphology
Categories
Funding
- National Natural Science Foundation of China [32000018, 82002123, 31930005, 31625002]
- Natural Science Foundation of Shanghai [19ZR1405100]
- National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) [R35GM124594]
- Kamangar family in the form of an endowed chair
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The study reported a case of C. auris candidemia in a patient in Xiamen, China, and reviewed the current reported cases of C. auris infection in the country. The research found at least two genetic clades of C. auris in China, with diverse biological and genetic features that may be associated with mating types of the isolates.
The recently emerged fungal pathogen Candida auris often displays resistance to one or more antifungal drugs. Its infections have been identified in at least 40 countries on six continents to date. Here we report a case of C. auris candidemia in a patient in Xiamen, a city in south China. We also review currently reported cases of C. auris infection in China and compare the genetic and biological features of C. auris strains isolated from this country. Our phylogenetic analysis indicates that there are at least two C. auris genetic clades present in China (the South African clade and the south Asian clade) that display opposite mating type loci (one is MTLa and the other is MTL alpha). We also found that there are several distinct features among the clinical isolates studied, including the expression of virulence factors, antifungal susceptibilities, and cellular morphologies, and that these features could be associated with the mating-type of the isolate. For example, C. auris MTLa isolates generally secreted higher levels of secreted aspartyl proteases (Saps) at ambient environmental temperatures. Taken together, this study demonstrates that C. auris clinical isolates from China exhibit diversity in both biological and genetic features.
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