A New Perspective of COVID-19 Infection: An Epigenetics Point of View

Review Biochemistry & Molecular Biology

Epigenetic mechanisms regulating COVID-19 infection

Sarantis Chlamydas et al.

Summary: The COVID-19 outbreak originating in Wuhan, China poses a significant global threat to human health. The highly contagious SARS-CoV-2 infection and transmission, along with age-related factors and epigenetic changes, play key roles in the pathophysiology of the virus. Epigenetic research has shown that factors such as global DNA methylation and host cell epigenetic modulation following infection may influence host susceptibility to viral infection.

EPIGENETICS (2021)

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Article Cell Biology

Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19

Michael J. Corley et al.

Summary: Severe COVID-19 patients show distinct epigenetic features in DNA methylation, including hypermethylation of IFN-related genes and hypomethylation of inflammatory genes. These results can help elucidate the pathogenic mechanisms, predict disease severity, and mortality risk.

JOURNAL OF LEUKOCYTE BIOLOGY (2021)

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Article Microbiology

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

Guido Papa et al.

Summary: Research suggests that furin plays a promoting role in SARS-CoV-2 infectivity and cell-cell spread, but it is not essential, indicating that furin inhibitors may reduce but not completely prevent viral spread.

PLOS PATHOGENS (2021)

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Article Biochemistry & Molecular Biology