Journal
RSC CHEMICAL BIOLOGY
Volume 3, Issue 4, Pages 407-419Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cb00007e
Keywords
-
Funding
- Shandong Provincial Natural Science Foundation, China [ZR2021QB152]
- Faculty start-up funds of Jining Medical University
- college students' Innovative Entrepreneurial Training Plan Program of Jining Medical University [S201910443002]
- Shenzhen Bay Laboratory, Shenzhen, China [SZBL2020090501008]
- Research Grants Council of Hong Kong SAR, China [AoE/P-705/16, 17301118, 17111319, 17303220, 17300321, C7005-20G]
- NSFC of China [21877093, 91953119]
- Laboratory for Synthetic Chemistry and Chemical Biology'' under the Health@InnoHK Program by the Innovation and Technology Commission, Hong Kong SAR, China
Ask authors/readers for more resources
The DNA-encoded chemical library (DEL) is a powerful technology platform in drug discovery that has been widely adopted in the pharmaceutical industry. Recent innovations, such as the DNA-encoded dynamic library (DEDL), have expanded the application scope of DELs and allowed for the discovery of unique ligands in complex biological systems.
The DNA-encoded chemical library (DEL) has emerged as a powerful technology platform in drug discovery and is also gaining momentum in academic research. The rapid development of DNA-/DEL-compatible chemistries has greatly expanded the chemical space accessible to DELs. DEL technology has been widely adopted in the pharmaceutical industry and a number of clinical drug candidates have been identified from DEL selections. Recent innovations have combined DELs with other legacy and emerging techniques. Among them, the DNA-encoded dynamic library (DEDL) introduces DNA encoding into the classic dynamic combinatorial libraries (DCLs) and also integrates the principle of fragment-based drug discovery (FBDD), making DEDL a novel approach with distinct features from static DELs. In this Review, we provide a summary of the recently developed DEDL methods and their applications. Future developments in DEDLs are expected to extend the application scope of DELs to complex biological systems with unique ligand-discovery capabilities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available