Efficacy of diffusion-weighted imaging in the diagnosis of osteoporosis suggested by the correlation between mandibular cortex width and apparent diffusion coefficient of the mandibular bone marrow

Purpose: The objectives of the study were as follows: (i) to compare MCW and ADC stratified by menopause and osteoporosis, (ii) to calculate the correlation of the MCW on panoramic radiographs with the ADC in the mandibular bone marrow, and (iii) to investigate the utility of DWI of the jaws in the diagnosis of osteoporosis. Material and Method: This study analyzed 87 normal patients and 23 patients with osteoporosis. The patients were divided into three groups: premenopausal (n = 33), postmenopausal (n = 54), and osteoporosis (n = 23). We investigated the MCW and mean ADC of the mandibular bone marrow. We analyzed the data using the Spearman's correlation coefficients, Kruskal-Wallis test, and post-hoc Mann-Whitney tests with Bonferroni adjustments, and a receiver operating characteristic (ROC) curve was plotted. Statistical significance was set at P < 0.05. Results: There were significant between-three group differences in both the mean ADC and mean MCW (p < 0.001). Furthermore, there was a significant positive correlation between MCW and the ADC of the mandibular bone marrow in postmenopausal group (p < 0.05). The ROC analysis revealed a cutoff ADC value of 0.62 to distinguish between the postmenopausal and those with osteoporosis. Conclusions: In addition to evaluating the MCW, which is currently used for osteoporosis evaluation, measuring the ADC of the mandibular bone marrow could contribute toward the examination of osteoporosis.

Automated summary

The study aimed to compare MCW and ADC in menopause and osteoporosis stratification, calculate the correlation between MCW on panoramic radiographs and ADC in mandibular bone marrow, and explore the utility of DWI in jaw osteoporosis diagnosis. The results showed significant differences in MCW and ADC among different groups, with a positive correlation between MCW and ADC in postmenopausal group. A cutoff ADC value of 0.62 was identified to distinguish postmenopausal group from those with osteoporosis.