Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 66, Issue 8, Pages 378-387Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1233415
Keywords
Bonding strength; burst strength; kaolin; montmorillonite; surgical sealants
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Funding
- Momentum fund (RAMOT), Tel Aviv University
- Kodesh foundation, Tel Aviv University
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Surgical sealants are an integral part of the surgical toolbox. They are used mainly to seal tissues or suture lines. In the current research, we examined a novel surgical sealant based on the natural polymers gelatin and alginate, crosslinked with carbodiimide and loaded with hemostatic agents. Incorporation of the hemostatic agent montmorillonite significantly improved the ex vivo burst strength and the other physical properties (swelling ratio, weight loss, curing time, and viscosity) of the basic surgical sealant, due to the formation of nanocomposite structure. This novel system presents a new approach for improving the physical properties of surgical sealants.
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