Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 65, Issue 12, Pages 619-628Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1157793
Keywords
Biomineralization; CaCO3; cytotoxicity; modulus; PVP-CMC
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Funding
- Ministry of Education, Youth and Sports of the Czech Republic - NPU Program I [LO1504]
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The authors focus on properties of biomineralized (CaCO3) PVP-CMC hydrogel (designated as I-X) including cytotoxicity assay using primary mouse embryonic fibroblasts. The biomineralized samples (VII-X) showed >80% cell viability, was selected for further characterizations. FTIR and XRD indicate deposition of CaCO3 within the PVP-CMC hydrogel matrix, SEM shows changes in morphology and pore diameter (VII and VIII: 1-12 mu m; IX: 10-70 mu m; X: 70-170 mu m), TGA determines the decomposition scenario of CaCO3, and tensile strength of samples (VII-X) ranged between 0.04 and 1.0GPa, which practically corresponds to the modulus of cancellous bone.
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