Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 66, Issue 6, Pages 280-288Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1201828
Keywords
Enhanced mechanical properties; enzymatic crosslinking; gelatin; hyaluronic acid; injectable hydrogels; protein-polysaccharide hydrogel
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Funding
- Spanish Ministry of Economy and Competitiveness [MAT2013-46467-C4-1-R, BES-2011-046144]
- VI National R&D&I Plan, Iniciativa Ingenio, Consolider Program
- Instituto de Salud Carlos III
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Gelatin injectable hydrogels have attracted attention for soft tissues regeneration; however, their poor mechanical properties limit their applications. The authors present a versatile strategy to enhance mechanical properties by mixing gelatin (Gel) with different proportions of hyaluronic acid (HA). The protein-polysaccharide systems are inspired by extracellular matrix and benefit from adhesive properties of RGD sequences in Gel and enhanced hydration and stiffness of HA. The authors were able to raise the Young's modulus from 4kPa to 6kPa and gelation times can be tuned between 4 to 9min, giving surgeons the option of adapting the material to specific requirements.
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