Journal
JOURNAL OF ELECTROCHEMICAL SCIENCE AND ENGINEERING
Volume 12, Issue 1, Pages 25-35Publisher
INT ASSOC PHYSICAL CHEMISTS-IAPC
DOI: 10.5599/jese.1116
Keywords
Nanomaterial; bio analytical method; RT PCR; portable biosensor
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Effective and efficient diagnosis of COVID-19 is crucial for expanding testing capabilities, with nucleic acid-based testing becoming the gold standard. Nano-enabled systems like electrochemical nanobiosensors are playing a significant role in advancing diagnostic technologies for COVID-19.
Early, rapid and ultrasensitive diagnosis of COVID-19 to facilitate high-throughput analysis without a high degree of technical expertise or sophisticated equipment is necessary to expand COVID-19 testing capability. Leveraging interdisciplinary proficiency in analytical chemistry, biomedical instrumentation, molecular biology, microfluidics, and nanotechnology, considerable advances have been made to develop a novel diagnostic tool that assures superior key performances for COVID-19 diagnosis. This review summarizes the nano-enabled systems such as electrochemical nanobiosensor for SARSCoV-2 virus detection and emphasizes promising diagnostic techniques to extensively facilitate the diagnostic practices during the COVID-19 pandemic. Currently, three main diagnostic methods have been widely used in the COVID-19 pandemic: nucleic acid (NA)based testing, computed tomography (CT), and serological testing. NA-based detection of SARS-CoV-2 such as Reverse transcription polymerase chain reaction has become the gold standard for COVID-19 diagnosis. This review congregates significant contributions in the electrochemical nanobiosensor research area, which is helpful for further nanobiosensor development. Although many efforts were taken to detect the SARS-CoV-2, the COVID 19 diagnosis still relies on expensive prolonged analysis. A rapid and reliable alternative is the utilization of a low-cost nanobiosensor for SARS-CoV-2 detection that can rapidly diagnose the disease even in asymptomatic conditions with high reliability and sensitivity.
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