Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 500, Issue 1-2, Pages 291-304Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2016.01.035
Keywords
Nanoemulsions; beta-Lactoglobulin; High pressure homogenization; Stability; Interfacial tension; Interfacial rheology
Categories
Funding
- Ministry of Higher Education of the Syrian Arab Republic
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To avoid the toxicological concerns associated to synthetic surfactants, proteins might be an alternative for the stabilization of pharmaceutical nanoemulsions. The present study investigates the use of beta-lactoglobulin (beta-lg) to stabilize oil in water biocompatible nanoemulsions intended for a pharmaceutical use and prepared by high pressure homogenization (HPH). The effects of composition (nature and weight fraction of oil, beta-lg concentration) and of process parameters (pressure and number of cycles) on the droplet size and on the stability of nanoemulsions were thoroughly assessed. The nanoemulsions prepared with beta-lg at 1 wt% and with 5 wt% Miglyol 812 (the oil with the lowest viscosity) displayed a relatively small particle size (about 200 nm) and a low polydispersity when a homogenization pressure of 100 MPa was applied for 4 cycles. These nanoemulsions were the most stable formulations over 30 days at least. Emulsification efficiency of beta-lg was reduced at higher homogenization pressures (200 MPa and 300 MPa). The effect of HPH process on the interfacial properties of beta-lg was evaluated by drop shape analysis. This treatment had an effect neither on the interfacial tension nor on the interfacial dilatational rheology of beta-lg at the Miglyol 812/water interface. (C) 2016 Elsevier B.V. All rights reserved.
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