Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 500, Issue 1-2, Pages 187-195Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2016.01.021
Keywords
Poly(D,L-lactic-co-glycolic acid); Polyethylene glycol; Poly(allyl glycidyl ether); Ovalbumin; Protein delivery; Drug delivery
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Funding
- BMBF in PeTrA project Plattform fur effizienten epithelialen Transport fur pharmazeutische Applikationen durch innovative partikulare Tragersysteme [13N11454]
- BMBF affirmative action Effizienter Wirkstofftransport in biologischen Systemen-BioMatVital: Biotransporter
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The effect of modifying the well-established pharmaceutical polymer PLGA by different PEG-containing block-copolymers on the preparation of ovalbumin (OVA) loaded PLGA nanoparticles (NPs) was studied. The used polymers contained poly(D,L-lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG) and poly (allyl glycidyl ether) (PAGE) as building blocks. The double emulsion technique yielded spherical NPs in the size range from 170 to 220 nm (PDI < 0.15) for all the differently modified polymers, allowing to directly compare protein loading of and release. PEGylation is usually believed to increase the hydrophilic character of produced particles, favoring encapsulation of hydrophilic substances. However, in this study simple PEGylation of PLGA had only a slight effect on protein release. In contrast, incorporating a PAGE block between the PEG and PLGA units, also eventually enabling active targeting introducing a reactive group, led to a significantly higher loading (+25%) and release rate (+100%), compared to PLGA and PEG-b-PLGA NPs. (C) 2016 Elsevier B.V. All rights reserved.
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