Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 511, Issue 1, Pages 198-204Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.07.009
Keywords
(trans) Dermal drug delivery; Hydrogenated phospholipid vesicles; Pig skin; Keratinocytes; DSC; Rheology
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In this work, diclofenac was encapsulated, as sodium salt, in glycerosomes containing 10, 20 or 30% of glycerol in the water phase with the aim to ameliorate its topical efficacy. Taking into account previous findings, glycerosome formulation was modified, in terms of economic suitability, using a cheap and commercially available mixture of hydrogenated soy phosphatidylcholine (P90H). P90H glycerosomes were spherical and multilamellar; photon correlation spectroscopy showed that obtained vesicles were similar to 131 nm, slightly larger and more polydispersed than those made with dipalmitoylphosphatidylcholine (DPPC) but, surprisingly, they were able to ameliorate the local delivery of diclofenac, which was improved with respect to previous findings, in particular using glycerosomes containing high amount of glycerol (20 and 30%). Finally, this drug delivery system showed a high in vitro biocompatibility toward human keratinocytes. (C) 2016 Elsevier B.V. All rights reserved.
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