Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 515, Issue 1-2, Pages 575-582Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2016.10.044
Keywords
Cystinosis; Ophthalmic delivery; Gel; Cysteamine; Preformulation
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Funding
- Sparks: The Children's Medical Research Charity
- Rooney Foundation
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Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal crystal deposition is one of the most troublesome complications affecting patients and requires the hourly administration of cysteamine eye drops. In an attempt to reduce this frequency and improve the treatment, the preformulation and evaluation of cysteamine containing gels is reported. Suitability for ophthalmic delivery was determined by analysis of rheology, bioadhesion, dissolution and stability. The results demonstrated that three polymers were suitable for ophthalmic delivery of cysteamine; namely sodium hyaluronate, hydroxyethyl cellulose and carbomer 934. Sodium hyaluronate displayed optimum performance in the preformulation tests, being pseudoplastic (reduction in apparent viscosity under increasing shear rate), bioadhesive, releasing cysteamine over 40 min and displaying stability over time. In conclusion these results offer the possibility to formulate cysteamine in an ocular applicable gel formulation. (C) 2016 Elsevier B.V. All rights reserved.
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