Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 513, Issue 1-2, Pages 554-563Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.09.051
Keywords
Biopolymers; Folate conjugation; Magnetic drug release; Magnetic resonance imaging; Drug delivery system
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Funding
- Higher Education Commission (HEC)
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In this study, Paclitaxel (PTX) containing, bovine serum albumin (BSA) nanoparticles were fabricated via a simple approach. Folic acid (FA) was conjugated to chitosan (CS)/carboxymethyl cellulose (CMC) through an esterification reaction to produce BSA-CS-FA or BSA-CMC-FA conjugates. NiFe2O4 noncore (NFs) and PTX were loaded through a heat treatment and by a diffusion process. NFs-BSA-CS and NFs-BSA-CMC-FA with size of about 80 nm, showed superior transversal R-2 relaxation rate of 349 (mM)(-1) s(-1) along with folate receptor-targeted and magnetically directed functions. NFs-BSA-CS-FA or NFs-BSA-CS-FA were found stable and biocompatible. Application of an external magnetic field effectively enhanced the PTX release from PTX-NFs-BSA-CS-FA or PTX-NFs-BSA-CS-FA and hence tumor inhibition rate. This study validate that NFs-BSA-CS-FA or NFs-BSA-CMC-FA and PTX-NFs-BSA-CS-FA or PTX-NFs-BSA-CS-FA are suitable systems for tumor diagnosis and therapy. (C) 2016 Published by Elsevier B.V.
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