Journal
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
Volume 6, Issue 7, Pages 771-777Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/TRPMS.2022.3140411
Keywords
Depth-of-interaction (DOI); event localization; single-photon emission computed tomography (SPECT)
Funding
- NIHR UCLH Biomedical Research Centre
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A prototype clinical brain single-photon emission computed tomography (SPECT) insert has been designed for use in simultaneous SPECT/MRI. The system incorporates novel slit-slat collimators and a statistical algorithm to determine the depth-of-interaction (DOI) for improved image performance. Monte Carlo simulation and experimental results showed the importance of DOI correction and suggested that four DOI layers may be sufficient. However, some limitations in event localization close to the readout plane were observed in the full clinical prototype.
A prototype clinical brain single-photon emission computed tomography (SPECT) insert has been designed for use in simultaneous SPECT/MRI. The system utilizes novel slit-slat collimators which, like pinhole collimators, suffers from parallax errors due to the large incident angle of photons. A statistical algorithm has been developed to determine the depth-of-interaction (DOI) with a view to improving image performance. The importance of DOI correction was demonstrated using Monte Carlo simulation. This simulation also indicated that four DOI layers (3 x 1.5 mm + 3.5 mm) may be sufficient. The improvement in event localization was demonstrated on a single detector before implementing the algorithm on the full clinical prototype where some limitations in event localization in layers close to the readout plane were observed. Nevertheless, DOI enabled the rejection of poorly localized events with improved resolution in reconstructed line sources.
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