Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 12, Issue -, Pages 197-206Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S121249
Keywords
iron oxide nanoparticles; surface functionalization; bioactive glycosaminoglycan; magnetic resonance imaging; cellular uptake; breast carcinoma
Funding
- National Natural Science Foundation of China [81201087, 81571665, 21074152, 51273216, J1103305]
- 973 Program of China [2015CB755500]
- Guangzhou Key Technology RD Program [1563000477, 201607010038]
- Natural Science Foundation of Guangdong Province in China [10151006001000010, 2014A030313647]
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Theranostic nanoparticles with both imaging and therapeutic abilities are highly promising in successful diagnosis and treatment of the most devastating cancers. In this study, the dual-modal imaging and photothermal effect of hyaluronan (HA)-modified superparamagnetic iron oxide nanoparticles (HA-SPIONs), which was developed in a previous study, were investigated for CD44 HA receptor-overexpressing breast cancer in both in vitro and in vivo experiments. Heat is found to be rapidly generated by near-infrared laser range irradiation of HASPIONs. When incubated with CD44 HA receptor-overexpressing MDA-MB-231 cells in vitro, HA-SPIONs exhibited significant specific cellular uptake and specific accumulation confirmed by Prussian blue staining. The in vitro and in vivo results of magnetic resonance imaging and photothermal ablation demonstrated that HA-SPIONs exhibited significant negative contrast enhancement on T-2-weighted magnetic resonance imaging and photothermal effect targeted CD44 HA receptor-overexpressing breast cancer. All these results indicated that HA-SPIONs have great potential for effective diagnosis and treatment of cancer.
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