Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 11, Issue -, Pages 5595-5610Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S104034
Keywords
gold nanorods; triple-negative breast cancer; Arg-Gly-Asp peptides; integrin alphaV beta3; megavoltage radiation therapy
Funding
- Shanghai Jiao Tong University [YG2012ZD02, 2JC1407400]
- Science and Technology Commission of Shanghai, People's Republic of China
- National Natural Science Foundation of China [81272506, 61227017]
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Multifunctional nanoprobes have great potential as effective radiosensitizers and drug carriers. RGD-modified gold nanorods could increase the uptake of nanoparticles via receptor-mediated endocytosis in integrin alphaV beta3-overexpressing breast cancer cells, which could enhance the effects of radiation on tumor cells, leading to further radiosensitization. The purpose of our study was to demonstrate that RGD-conjugated mesoporous silica-encapsulated gold nanorods significantly enhanced the sensitization of triple-negative breast cancer to megavoltage energy. The results indicated that RGD-conjugated mesoporous silica-encapsulated gold nanorod multifunctional nanoprobes could achieve radiosensitization in vitro and in vivo, which suggests the potential translation of this nanotechnology to clinical applications in tumor-targeting and selective therapy.
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