Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 11, Issue -, Pages 4819-4834Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S108847
Keywords
TiO2 nanotubes; anodization; drug delivery; orthopedic implant
Funding
- National Natural Science Foundation of People's Republic of China [21501127, 51502185]
- Natural Science Foundation of Jiangsu Province of People's Republic of China [BK20130313, BK20140400]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of People's Republic of China [15KJB430025]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- King Saud University, Vice Deanship of Scientific Research Chairs
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Titania nanotube (TNT) arrays are recognized as promising materials for localized drug delivery implants because of their excellent properties and facile preparation process. This review highlights the concept of localized drug delivery systems based on TNTs, considering their outstanding biocompatibility in a series of ex vivo and in vivo studies. Considering the safety of TNT implants in the host body, studies of the biocompatibility present significant importance for the clinical application of TNT implants. Toward smart TNT platforms for sustainable drug delivery, several advanced approaches were presented in this review, including controlled release triggered by temperature, light, radiofrequency magnetism, and ultrasonic stimulation. Moreover, TNT implants used in medical therapy have been demonstrated by various examples including dentistry, orthopedic implants, cardiovascular stents, and so on. Finally, a future perspective of TNTs for clinical applications is provided.
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