Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 11, Issue -, Pages 4327-4338Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S97441
Keywords
upconversion nanoparticles; polyaniline; upconversion luminescence; photothermal therapy
Funding
- National Natural Science Foundation of China [23173268]
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In this study, we developed a nanosystem based on upconversion nanoparticles (UCNPs) coated with a layer of polyaniline nanoparticles (PANPs). The UCNP induces upconversion luminescence for imaging and photothermal conversion properties are due to PANPs. In vitro experiments showed that the UCNPs-PANPs were nontoxic to cells even at a high concentration (800 mu g mL(-1)). Blood analysis and histological experiments demonstrated that the UCNPs- PANPs exhibited no apparent toxicity in mice in vivo. Besides their efficacy in photothermal cancer cell ablation, the UCNP-PANP nanosystem was found to achieve an effective in vivo tumor ablation effect after irradiation using an 808 nm laser. These results demonstrate the potential of the hybrid nanocomposites for use in imaging-guided photothermal therapy.
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