Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 11, Issue -, Pages -Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S117511
Keywords
nanostructured lipid carrier; topical delivery; controlled release; 5-fluorouracil; skin penetration; skin infection
Funding
- School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
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The aim of this study was to develop a nanostructured lipid carrier (NLC)-based hydrogel and study its potential for the topical delivery of 5-fluorouracil (5-FU). Precirol (R) ATO 5 (glyceryl palmitostearate) and Labrasol (R) were selected as the solid and liquid lipid phases, respectively. Poloxamer 188 and Solutol (R) HS15 (polyoxyl-15-hydroxystearate) were selected as surfactants. The developed lipid formulations were dispersed in 1% Carbopol (R) 934 (poly[ acrylic acid]) gel medium in order to maintain the topical application consistency. The average size, zeta potential, and polydispersity index for the 5-FU-NLC were found to be 208.32 +/- 8.21 nm, -21.82 +/- 0.40 mV, and 0.352 +/- 0.060, respectively. Transmission electron microscopy study revealed that 5-FU-NLC was <.200 nm in size, with a spherical shape. In vitro drug permeation studies showed a release pattern with initial burst followed by sustained release, and the rate of 5-FU permeation was significantly improved for 5-FU-NLC gel (10.27 +/- 1.82 mu g/cm(2)) as compared with plain 5-FU gel (2.85 +/- 1.12 mu g/cm(2)/h). Further, skin retention studies showed a significant retention of 5-FU from the NLC gel (91.256 +/- 4.56 mu g/cm(2)) as compared with that from the 5-FU plain gel (12.23 +/- 3.86 mu g/cm(2)) in the rat skin. Skin irritation was also significantly reduced with 5-FU-NLC gel as compared with 5-FU plain gel. These results show that the prepared 5-FU-loaded NLC has high potential to improve the penetration of 5-FU through the stratum corneum, with enormous retention and with minimal skin irritation, which is the prerequisite for topically applied formulations.
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