Journal
MICROBIAL CELL
Volume 9, Issue 2, Pages 24-41Publisher
SHARED SCIENCE PUBLISHERS OG
DOI: 10.15698/mic2022.02.769
Keywords
Salmonella; molecular motors; type 3 secretion system; effectors
Categories
Funding
- China Scholarship Council
- Institut National de la Sante et de la Recherche Medicale
- Centre National de la Recherche Scientifique
- Aix-Marseille University
- Agence Nationale de la Recherche [ANR-16-CE15-0023-01]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE15-0023] Funding Source: Agence Nationale de la Recherche (ANR)
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Salmonellae are bacteria that reside in infected host cells and replicate through the formation of membrane compartments. This review focuses on the role and significance of membrane compartment remodeling in infected cells, as well as the bacterial and host cell pathways involved.
Salmonellae are bacteria that cause moderate to severe infections in humans, depending on the strain and the immune status of the infected host. These pathogens have the particularity of residing in the cells of the infected host. They are usually found in a vacuolar compartment that the bacteria shape with the help of effector proteins. Following invasion of a eukaryotic cell, the bacterial vacuole undergoes maturation characterized by changes in localization, composition and morphology. In particular, membrane tubules stretching over the microtubule cytoskeleton are formed from the bacterial vacuole. Although these tubules do not occur in all infected cells, they are functionally important and promote intracellular replication. This review focuses on the role and significance of membrane compartment remodeling observed in infected cells and the bacterial and host cell pathways involved.
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