Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms17122022
Keywords
inflammation; aging; depression; late-life
Funding
- Research Network Center of Mental Health-CIBERSAM [2010-P-02]
- Government of Spain Health Research Fund FEDER [PI08-1213, PI11-01977, PI14-01900, PI08-0873, PI10-01746, PS09/02002, PI12/02077, PI15-00789, PI13/00451]
- Ministry of Health and Social Equality Policy [20111064]
- Department of Education, Language Policy and Culture of the Basque Government [200911147, 2013111162, 2010111170, SAIO10-PC10BF01]
- European Comission [UE/2012/FI-STAR]
- University of the Basque Country [GIC10/80, GIC12/84]
- Basque Foundation for Health Innovation and Research-BIOEF
- Stanley Research Foundation [03-RC-003]
- NIHR Cambridge Biomedical Research Centre
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Depressive disorders appear relatively frequently in older patients, and therefore represent an important disease burden worldwide. Given the high levels of inflammatory parameters found in depressed elderly patients, the inflammaging hypothesis is gaining strength. In this systematic review, we summarize current evidence regarding the relationship between inflammatory parameters and late-life depression, with a unique focus on longitudinal studies to guarantee temporality. According to the data summarized in this review, the levels of some proinflammatory parameters-especially interleukin (IL)-8, IL-6, and tumor necrosis factor (TNF)-alpha-could serve as biomarkers for the future development of depressive symptoms in elderly patients. Proinflammatory cytokines seem to be associated with the future development of clinically significant depression, irrespective of baseline scores, thus indicating that inflammation temporally precedes and increases depression risk. As insufficient research has been conducted in this field, further prospective studies are clearly warranted.
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