Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 17, Issue 3, Pages -Publisher
MDPI AG
DOI: 10.3390/ijms17030423
Keywords
antimicrobial peptides; host defense; infection; ribonuclease 7; ribonuclease; innate immunity
Funding
- National Institute of Health Grant (NIDDK) [K08 DK102594, K08 DK094970]
- NIDDK Diabetic Complications Consortium Grant [DK076169]
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The Ribonuclease A Superfamily is composed of a group of structurally similar peptides that are secreted by immune cells and epithelial tissues. Several members of the Ribonuclease A Superfamily demonstrate antimicrobial activity, and it has been suggested that some of these ribonucleases play an essential role in host defense. Ribonuclease 7 (RNase 7) is an epithelial-derived secreted peptide with potent broad-spectrum antimicrobial activity. This review summarizes the published literature on RNase 7's antimicrobial properties, structure, regulation, and contributions to host defense. In doing so, we conclude by highlighting key knowledge gaps that must be investigated to completely understand the potential of developing RNase 7 as a novel therapeutic for human infectious diseases.
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