4.1 Review

Milestones in Tremor Research: 10 Years Later

Related references

Note: Only part of the references are listed.
Article Neurosciences

Cerebellar Oscillations in Familial and Sporadic Essential Tremor

Shi-Bing Wong et al.

Summary: Enhanced cerebellar oscillations were found in patients with ET, with both familial and sporadic ET cases showing increased intensity compared to controls. Interestingly, the correlation between cerebellar oscillations and tremor severity differed between familial and sporadic ET cases, indicating diverse cerebellar pathophysiology.

CEREBELLUM (2022)

Article Clinical Neurology

Probabilistic Mapping of Deep Brain Stimulation: Insights from 15 Years of Therapy

Gavin J. B. Elias et al.

Summary: Deep brain stimulation (DBS) relies on precise delivery of electrical current to target tissues, with the identification of neuroanatomical substrates playing a key role in predicting clinical outcomes. Probabilistic stimulation maps (PSMs) can guide the prediction of clinical responses by overlapping with individual patients' activation volumes. Future advancements in individualized models incorporating mapping techniques and patient-specific clinical variables are likely to enhance DBS target selection and improve patient outcomes.

ANNALS OF NEUROLOGY (2021)

Article Multidisciplinary Sciences

Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence

Sebastian R. Schreglmann et al.

Summary: The study introduces a new method for real-time tracking of neural oscillations, which can be used to suppress aberrant neural oscillations associated with specific disorders, offering a new approach for the treatment of brain disorders.

NATURE COMMUNICATIONS (2021)

Article Biophysics

The development of an implantable deep brain stimulation device with simultaneous chronic electrophysiological recording and stimulation in humans

Abhinav Goyal et al.

Summary: Deep brain stimulation (DBS) is commonly used to treat neurological disorders, but there is a need for a fully-implantable DBS system that can chronically record patient-specific electrophysiological biomarkers to improve therapeutic benefit. The Percept PC is the first FDA-approved device capable of simultaneous recordings and stimulation, with potential applications beyond DBS in understanding normal and abnormal neurophysiology.

BIOSENSORS & BIOELECTRONICS (2021)

Article Clinical Neurology

Features of ET plus correlate with age and tremor duration: ET plus may be a disease stage rather than a subtype of essential tremor

Elan D. Louis et al.

Summary: As patients with essential tremor (ET) age and the duration of tremor increases, they tend to develop more features of ET plus, which may represent a disease stage rather than a distinct subtype of the disease.

PARKINSONISM & RELATED DISORDERS (2021)

Article Neurosciences

Essential Tremor versus ET-plus: A Detailed Postmortem Study of Cerebellar Pathology

John T. Gionco et al.

Summary: This study found no significant pathological differences in cerebellar cortex between cases of ET and ET-plus, thus not supporting the idea that ET and ET-plus represent distinct clinical-pathological entities.

CEREBELLUM (2021)

Article Clinical Neurology

ET Plus: Instability of the Diagnosis During Prospective Longitudinal Follow-up of Essential Tremor Cases

Daniella Iglesias-Hernandez et al.

Summary: The study found that the prevalence of ET plus increases progressively over time, but the stability of ET plus diagnosis fluctuates. Rest tremor is the most unstable clinical feature of ET plus, while the reversion rate of memory impairment is relatively low.

FRONTIERS IN NEUROLOGY (2021)

Article Clinical Neurology

The Signature of Primary Writing Tremor Is Dystonic

Anna Latorre et al.

Summary: The study found that primary writing tremor and dystonic tremor syndrome share similar patterns of electrophysiological abnormalities, supporting the hypothesis of a common pathophysiology between them.

MOVEMENT DISORDERS (2021)

Article Clinical Neurology

Wearable sensor-driven responsive deep brain stimulation for essential tremor

Stephanie Cernera et al.

Summary: The study aimed to establish a physiology-driven responsive DBS system for personalized therapy in ET based on EMG signals. Results showed that EMG-driven rDBS provides clinically equivalent tremor suppression compared to traditional cDBS, while delivering less total electrical energy, leading to increased battery life of the INS.

BRAIN STIMULATION (2021)

Article Clinical Neurology

Different effects of essential tremor and Parkinsonian tremor on multiscale dynamics of hand tremor

Dongning Su et al.

Summary: The study investigated the multiscale dynamics of hand tremor in ET and PT patients, revealing lower complexity in ET compared to PT and the potential of complexity metric in distinguishing between the two conditions. Hand tremor complexity was found to be associated with disease duration and severity, serving as a promising diagnostic marker for ET and PT differentiation.

CLINICAL NEUROPHYSIOLOGY (2021)

Review Clinical Neurology

Myogenic tremor - a novel tremor entity

Jochen Schaefer et al.

Summary: Tremor is a common neurological symptom with various potential causes, most commonly linked to pacemakers in the central nervous system. Myogenic tremor, a recently discovered type of tremor believed to originate in muscle itself, presents as a high frequency, postural, and kinetic tremor. The tremor is thought to be generated in the sarcomere and may be a valuable clinical tool for differentiating myopathies.

CURRENT OPINION IN NEUROLOGY (2021)

Article Clinical Neurology

Bilateral Focused Ultrasound Thalamotomy for Essential Tremor (BEST-FUS Phase 2 Trial)

Christian Iorio-Morin et al.

Summary: This study demonstrated that staged bilateral magnetic resonance-guided focused ultrasound thalamotomy can significantly improve quality of life and tremor symptoms in patients with medically refractory essential tremor, with a reasonable safety profile.

MOVEMENT DISORDERS (2021)

Review Clinical Neurology

Essential tremor-plus: a controversial new concept

Elan D. Louis et al.

LANCET NEUROLOGY (2020)

Article Neurosciences

Pallidal Activity in Cervical Dystonia with and Without Head Tremor

Alexey Sedov et al.

CEREBELLUM (2020)

Article Clinical Neurology

Functional disconnection of the dentate nucleus in essential tremor

Sankalp Tikoo et al.

JOURNAL OF NEUROLOGY (2020)

Article Clinical Neurology

Current and Emerging Treatments of Essential Tremor

William George Ondo

NEUROLOGIC CLINICS (2020)

Article Neurosciences

Magnetic Resonance-Guided Focused Ultrasound Thalamotomy to Treat Essential Tremor in Nonagenarians

Michelle Paff et al.

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY (2020)

Review Clinical Neurology

Tremor pathophysiology: lessons from neuroimaging

A. M. Madelein van der Stouwe et al.

CURRENT OPINION IN NEUROLOGY (2020)

Article Clinical Neurology

Multimodal MRI for MRgFUS in essential tremor: post-treatment radiological markers of clinical outcome

Anish N. Kapadia et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2020)

Article Neurosciences

The Pathophysiology of Dystonic Tremors and Comparison With Essential Tremor

Pattamon Panyakaew et al.

JOURNAL OF NEUROSCIENCE (2020)

Article Clinical Neurology

Do We Belittle Essential Tremor by Calling It a Syndrome Rather Than a Disease? No

Rodger J. Elble

FRONTIERS IN NEUROLOGY (2020)

Letter Clinical Neurology

Deep brain stimulation of the ventralis oralis anterior thalamic nucleus is effective for dystonic tremor

L. Mongardi et al.

PARKINSONISM & RELATED DISORDERS (2020)

Article Engineering, Biomedical

Fully implanted adaptive deep brain stimulation in freely moving essential tremor patients

B. Ferleger et al.

JOURNAL OF NEURAL ENGINEERING (2020)

Article Clinical Neurology

Shorter pulse width reduces gait disturbances following deep brain stimulation for essential tremor

Daniel Kroneberg et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Article Medicine, Research & Experimental

An Acute Randomized Controlled Trial of Noninvasive Peripheral Nerve Stimulation in Essential Tremor

Rajesh Pahwa et al.

NEUROMODULATION (2019)

Article Clinical Neurology

Novel mutations in MYBPC1 are associated with myogenic tremor and mild myopathy

Janis Stavusis et al.

ANNALS OF NEUROLOGY (2019)

Review Clinical Neurology

MDS evidence-based review of treatments for essential tremor

Joaquim J. Ferreira et al.

MOVEMENT DISORDERS (2019)

Article Clinical Neurology

Contextualizing the pathology in the essential tremor cerebellar cortex: a patholog-omics approach

Elan D. Louis et al.

ACTA NEUROPATHOLOGICA (2019)

Review Clinical Neurology

Tremor Habituation to Deep Brain Stimulation: Underlying Mechanisms and Solutions

Alfonso Fasano et al.

MOVEMENT DISORDERS (2019)

Article Clinical Neurology

What Is Essential About Essential Tremor? A Diagnostic Placeholder

Alfonso Fasano et al.

MOVEMENT DISORDERS (2018)

Article Clinical Neurology

Thalamic Directional Deep Brain Stimulation for tremor: Spend less, get more

P. Rebelo et al.

BRAIN STIMULATION (2018)

Article Clinical Neurology

The nature of postural tremor in Parkinson disease

Michiel F. Dirkx et al.

NEUROLOGY (2018)

Article Clinical Neurology

The overlap between Essential tremor and Parkinson disease

Musleh Algarni et al.

PARKINSONISM & RELATED DISORDERS (2018)

Article Clinical Neurology

Stimulating at the right time: phase-specific deep brain stimulation

Hayriye Cagnan et al.

BRAIN (2017)

Review Clinical Neurology

Essential Pitfalls in Essential Tremor

Alberto J. Espay et al.

MOVEMENT DISORDERS (2017)

Article Clinical Neurology

MRI-guided focused ultrasound thalamotomy in non-ET tremor syndromes

Alfonso Fasano et al.

NEUROLOGY (2017)

Article Clinical Neurology

Task-dependent variability of Essential Tremor

Nicole Schuhmayer et al.

PARKINSONISM & RELATED DISORDERS (2017)

Review Clinical Neurology

Transducer-based evaluation of tremor

Dietrich Haubenberger et al.

MOVEMENT DISORDERS (2016)

Article Medicine, General & Internal

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor

W. Jeffrey Elias et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Clinical Neurology

Tremor pattern differentiates drug-induced resting tremor from Parkinson disease

R. Nistico et al.

PARKINSONISM & RELATED DISORDERS (2016)

Article Clinical Neurology

Genetics of essential tremor

Murni Tio et al.

PARKINSONISM & RELATED DISORDERS (2016)

Article Clinical Neurology

Impaired eye blink classical conditioning distinguishes dystonic patients with and without tremor

E. Antelmi et al.

PARKINSONISM & RELATED DISORDERS (2016)

Article Clinical Neurology

Somatosensory temporal discrimination in essential tremor and isolated head and voice tremors

Antonella Conte et al.

MOVEMENT DISORDERS (2015)

Article Clinical Neurology

Essential and aging-related tremor: Differences of central control

Muthuraman Muthuraman et al.

MOVEMENT DISORDERS (2015)

Letter Clinical Neurology

Purkinje cell loss is neither pathological basis nor characteristic of essential tremor

A. H. Rajput et al.

PARKINSONISM & RELATED DISORDERS (2013)

Article Biophysics

SENSING OF PATHOLOGICAL TREMOR USING SURFACE ELECTROMYOGRAPHY AND ACCELEROMETER FOR REAL-TIME ATTENUATION

Ferdinan Widjaja et al.

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY (2011)

Review Clinical Neurology

Milestones in Tremor Research

Rodger Elble et al.

MOVEMENT DISORDERS (2011)

Article Clinical Neurology

Essential tremor associated with focal nonnigral Lewy bodies - A clinicopathologic study

ED Louis et al.

ARCHIVES OF NEUROLOGY (2005)