Journal
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
Volume 38, Issue -, Pages 27-31Publisher
WILEY
DOI: 10.1111/ijlh.12507
Keywords
Phospholipid; syndrome; testing; laboratory
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This is a practical report on laboratory tests for the diagnosis of antiphospholipid syndrome (APS). After a general definition of APS, this study deals with appropriateness and timing in requesting the determination of antiphospholipid (aPL) antibodies. Lupus anticoagulant (LAC), anticardiolipin (aCL), and anti 2-glycoprotein I (aGPI) are the mandatory tests to be performed, while other tests are not yet validated for clinical use. Interpretation of results is an important discussed issue that implies a close liaison between clinical pathologists and clinicians. Finally, a personal definition of APS according to aPL antibody profile closes the manuscript.
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