Inequalities in Glycemic Control in Youth with Type 1 Diabetes Over Time: Intersectionality Between Socioeconomic Position and Race and Ethnicity

Background Racial/ethnic health inequities have been well-documented among youth and young adults with type 1 diabetes (T1D), yet little is known about how socioeconomic position (SEP) intersects with the risk marker of race/ethnicity to predict inequities in longitudinal glycemic control. Purpose To identify patterns of SEP, race/ethnicity, and clinical characteristics that differentiate hemoglobin A1c (HbA(1c)) trajectories among youth and young adults after T1D diagnosis. Methods The SEARCH for Diabetes in Youth cohort includes youth with diabetes diagnosed from 2002 to 2006 and 2008 who were followed through 2015. We analyzed data from 1,313 youth and young adults with T1D with >= 3 HbA(1c) measures. Classification tree analysis identified patterns of baseline demographic, SEP, and clinical characteristic that best predicted HbA(1c) trajectories over an average of 8.3 years using group-based trajectory modeling. Results Two HbA(1c) trajectories were identified: Trajectory 1 (77%) with lower baseline HbA(1c) and mild increases (from mean 7.4% to 8.4%) and Trajectory 2 (23%) with higher baseline HbA(1c) and major increases (from 8.5% to 11.2%). Race/ethnicity intersected with different SEP characteristics among non-Hispanic white (NHW) than in non-whites. Public health insurance predicted high-risk Trajectory 2 membership in non-whites, whereas parental education, household structure, diagnosis age and glucose checking frequency predicted membership for NHW youth and young adults. Two characteristics, race/ethnicity and parental education alone identified 80% of the Trajectory 2 members. Conclusions Race/ethnicity intersects with multiple SEP and clinical characteristics among youth and young adults with T1D, which is associated with particularly high risk of poor long-term glycemic control.

Automated summary

This study finds that race/ethnicity interacts with socioeconomic position and clinical characteristics, resulting in a higher risk of poor glycemic control among youth and young adults with type 1 diabetes.