Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 52, Issue -, Pages 55-58Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2016.10.002
Keywords
Rapid influenza detection test; Influenza; Viral isolation
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Funding
- Morinaga Milk Industry Co., Ltd, Tokyo, Japan
- Institute of Immunology Co., Ltd, Tokyo, Japan
- Grants-in-Aid for Scientific Research [15K09584] Funding Source: KAKEN
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As the characteristics and accuracy of rapid influenza detection tests (RIDTs) vary, the development of a high-performance RIDT has been eagerly anticipated. In this study, the new RIDT GOLD SIGN FLU and the existing RIDT Quick Navi-Flu were evaluated in terms of detecting the antigens of influenza viruses A and B in Japanese adults with influenza-like symptoms. The study was performed from December 2013 to March 2014. Among the 123 patients from whom nasopharyngeal swab specimens were collected, 59 tested positive by viral isolation as the gold standard method (influenza A, n = 38; influenza B, n = 21). For GOLD SIGN FLU, the sensitivities were 73.7% and 81.0%, and the specificities were 97.6% and 98.0% for influenza A and B, respectively. For Quick Navi-Flu, the sensitivities were 86.8% and 85.7%, and the specificities were 98.8% and 100% for influenza A and B, respectively. The time to the appearance of the line on the test strip was less than 3 min for influenza A and less than 2 min for influenza B with both RIDTs in more than 90% of cases. GOLD SIGN FLU was useful for diagnosing influenza A, and the result was readily available for influenza B particularly among adult patients. Quick Navi-Flu showed better sensitivities and specificities than GOLD SIGN FLU. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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