Journal
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
Volume 50, Issue -, Pages 10-17Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2016.07.006
Keywords
Morganella morganii; epidemiology; resistant genes; disease spectrum; risk factors
Categories
Funding
- National Natural Science Foundation of China [31170159]
- Natural Science Foundation of Chongqing City [CSTC2011jjA10070]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
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Morganella morganii belongs to the tribe Proteeae of the Enterobacteriaceae family. This species is considered as an unusual opportunistic pathogen that mainly causes post-operative wound and urinary tract infections. However, certain clinical M. morganii isolates present resistance to multiple antibiotics by carrying various resistant genes (such as blaNDM-1, and qnrD1), thereby posing a serious challenge for clinical infection control. Moreover, virulence evolution makes M. morganii an important pathogen. Accumulated data have demonstrated that M. morganii can cause various infections, such as sepsis, abscess, purple urine bag syndrome, chorioamnionitis, and cellulitis. This bacterium often results in a high mortality rate in patients with some infections. M. morganii is considered as a non-negligent opportunistic pathogen because of the increased levels of resistance and virulence. In this review, we summarized the epidemiology of M. morganii, particularly on its resistance profile and resistant genes, as well as the disease spectrum and risk factors for its infection. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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