Journal
DERMATOLOGY PRACTICAL & CONCEPTUAL
Volume 12, Issue 1, Pages -Publisher
MATTIOLI 1885
DOI: 10.5826/dpc.1201a37
Keywords
anti-CD20 antibodies; neonatal Fc receptor (FcRn); pemphigus; rituximab; treatment
Categories
Ask authors/readers for more resources
Pemphigus vulgaris (PV) is an autoimmune blistering disease. Glucocorticoids have improved the prognosis of patients with PV, but long-term use can lead to adverse effects. Rituximab and other antibody therapies have shown promising results in the treatment of PV.
Pemphigus vulgaris (PV) belongs to the group of autoimmune blistering diseases. PV can affect not only mucous membranes, but also the skin and it is characterized by serum IgG autoantibodies against desmoglein 1 and 3, two major components of desmosomes. The introduction of glucocorticoids improved dramatically the prognosis of patients affected by PV. However, long-term use of high dose corticosteroids and adjuvant steroid-sparing immunosuppressants can lead to several adverse events. Rituximab, a chimeric anti-CD20 monoclonal antibody, has been recently approved as in-label therapy for PV, leading to an improvement of the prognosis and higher remission rate. Furthermore, other anti B-cell therapies and several anti-CD20 biosimilars have been introduced in the clinical practice. We focused on present and future therapeutic approaches in PV.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available