Journal
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
Volume 29, Issue 4, Pages 805-811Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0394632016672218
Keywords
alpha-naphthyl isothiocyanate; Emodin; farnesoid X receptor (FXR); intrahepatic cholestasis
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Funding
- National Science Foundation of China [81403434, 81371840]
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The aim of this study is to investigate Emodin on alleviating intrahepatic cholestasis by regulation of liver farnesoid X receptor (FXR) pathway. Cell and animal models of intrahepatic cholestatis were established. Biochemical tests and histomorphology were performed. The messenger RNA (mRNA) and protein expression of FXR, small heterodimer partner (SHP), uridine diphosphate glucuronosyltransferase 2 family polypeptide B4 (UGT2B4), and bile salt export pump (BSEP) was detected. As a result, compared with the model group, the serum levels of biochemical test were significantly lower in the Emodin group (P < 0.01). The histopathological changes were remitted significantly by Emodin treatment. In the model group, the mRNA and protein expression of FXR, SHP, UGT2B4, and BSEP was significantly lower than in the normal group in cell models (P < 0.05). With Emodin intervention, the expression of FXR, SHP, UGT2B4, and BSEP was notably increased (P < 0.05). In conclusion, Emodin plays a protective role in intrahepatic cholestasis by promoting FXR signal pathways.
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