Journal
NPJ DIGITAL MEDICINE
Volume 4, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41746-021-00536-y
Keywords
-
Funding
- National Science Foundation [DBI-1759487, DBI-1552309, DBI-1355899, DGE-1762114, DGE-1256082]
- National Institutes of Health [R35 GM 128638, R01 NIA AG 061132]
Ask authors/readers for more resources
The article introduces a transferable embedding method named PHASE for accurately forecasting adverse surgical outcomes based on physiological signals. Through comparison on over 50,000 surgeries and ICU data, it is found that PHASE outperforms other state-of-the-art approaches in predicting six distinct outcomes.
Hundreds of millions of surgical procedures take place annually across the world, which generate a prevalent type of electronic health record (EHR) data comprising time series physiological signals. Here, we present a transferable embedding method (i.e., a method to transform time series signals into input features for predictive machine learning models) named PHASE (PHysiologicAl Signal Embeddings) that enables us to more accurately forecast adverse surgical outcomes based on physiological signals. We evaluate PHASE on minute-by-minute EHR data of more than 50,000 surgeries from two operating room (OR) datasets and patient stays in an intensive care unit (ICU) dataset. PHASE outperforms other state-of-the-art approaches, such as long-short term memory networks trained on raw data and gradient boosted trees trained on handcrafted features, in predicting six distinct outcomes: hypoxemia, hypocapnia, hypotension, hypertension, phenylephrine, and epinephrine. In a transfer learning setting where we train embedding models in one dataset then embed signals and predict adverse events in unseen data, PHASE achieves significantly higher prediction accuracy at lower computational cost compared to conventional approaches. Finally, given the importance of understanding models in clinical applications we demonstrate that PHASE is explainable and validate our predictive models using local feature attribution methods.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available