Bisphenol A exposure may increase the risk of development of atopic disorders in children

Background: Little is known about the effect of Bisphenol A (BPA) on atopic disorders. Objective: To investigated the associations (i) between postnatal BPA exposure and allergic diseases in children; (ii) between BPA and IgE levels for the possible disease pathogenesis; and (iii) gender-based differences. Methods: A total of 453 children from Childhood Environment and Allergic Diseases Study cohort with urine and blood samples were recruited in Taiwan. Urinary BPA glucoronide (BPAG) levels were measured by UPLC-MS/MS at ages 3 and 6 years. The associations between BPAG levels at different ages and IgE levels and the development of allergic diseases were evaluated by multivariate linear regression and logistic regression. A mediation analysis was also conducted to evaluate how much risk of allergic diseases in relation to BPA exposure is explained by IgE changes. Results: The BPAG levels at age 3 were positively associated with IgE levels at age 3 (beta = 64.85 kU/l per In-unit increase BPAG level; 95% Cl, 14.59-115.11 kU/l). Stratified by gender, BPAG levels at age 3 were positively associated with IgE levels at age 3, particularly in girls (beta = 139.23 kW; 95% Cl, 57.38-221.09 kU/l). Similar results were also found at age 6. Urinary BPAG levels at age 3 were significantly associated with asthma at ages 3 and 6, with OR (95%CI) of 1.29(1.08-1.55) and 1.27(1.04-1.55). We estimated that 70% of the total effect of BPA exposure on asthma is mediated by IgE levels. Conclusions: BPA exposures were associated with IgE levels and may increase the risk of development of allergic diseases in children particularly in girls. (C) 2015 Elsevier GmbH. All rights reserved.