Journal
PHARMACOLOGY RESEARCH & PERSPECTIVES
Volume 9, Issue 5, Pages -Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/prp2.787
Keywords
clinical trials; female hygienic products; female urogenital tract; live biotherapeutic products; probiotics; urogenital tract infections
Categories
Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas, Argentina (CONICET) [PIP 545]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 2017-4324, PICT 2018-00670]
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This article discusses the importance of lactobacilli in the healthy human vagina and the potential use of probiotics for preventing and treating female urogenital tract infections. It emphasizes the list of requirements for developing probiotic products/formulas for the female UGT.
Lactobacilli are the predominant microorganisms of the healthy human vagina. A novel alternative for the prevention and treatment of female urogenital tract infections (UGTI) is the inclusion of these microorganisms as active pharmaceutical ingredients in probiotic formulas, and more recently in female hygienic products. Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. A list of requirements must be considered during the development of probiotic product/formula for the female urogenital tract (UGT). This review aims to resume the requirements, probiotic characteristics, and clinical trial applied to determine the effect of probiotic and potentially probiotic strains on different woman's physiological and pathological conditions, and in preterm birth prevention. A revision of female hygienic products available in the world market is included, together with novel studies applying nanotechnology for Lactobacillus incorporation in hygienic products. Further studies and well-designed clinical trials are urgently required to complement the current knowledge and applications of probiotics in the female UGT. The use of probiotic formulas and products will improve and restore the ecological equilibrium of the UGT microbiome to prevent and treat UGTI in women under different conditions.
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